职      称: 副教授，博士生导师

电      话: 13419508950

电子邮件: dlu@hust.edu.cn

地      址: 武汉市洪山区珞喻路1037号华中科技大学

办 公  室: 化学楼 909室

专业方向: 有机化学

研究领域: 合成方法学，含氧小分子的活化，选择性自由基反应

  教育/培训经历

2003年09月-2007年06月 华中科技大学 应用化学 理学学士

2007年09月-2012年06月 华中科技大学 无机化学 博士

2011年12月-2012年05月 The University of Iowa, College of Pharmacy, Visiting Scholar

  工作及科研经历

2012年07月-2016年12月 Georgia State University, Department of Chemistry, 博士后

2016年12月-今 华中科技大学 化学与化工学院 副教授

 研究方向

• 博士阶段主要从事手性催化剂的设计合成，以及不对称催化方法学的研究，导师为龚跃法教授。

• 博士后期间，研究方向为铁催化的自由基烯烃双官能团化反应，以及氮自由基和三氟甲基自由基物种产生的新方法。

• 开始独立工作后，我的研究兴趣主要集中在可再生的含氧小分子的自由基转化方面。我们试图通过探索新型的碳-氢与碳-氧键活化途径，建立可控的烷基自由基产生方法，将含氧小分子应用在选择性的有机合成反应中。

 发表论文

工作阶段：

22. Peng Wang, Yunxuan Luo, Songsong Zhu, Dengfu Lu* and Yuefa Gong* Adv. Synth. Catal. 2019, DOI: 10.1002/adsc.201901041,"Catalytic Azido‐Hydrazination of Alkenes Enabled by Visible Light: Mechanistic Studies and Synthetic Applications"

21. Sen Yang, Shuangyu Zhu, Dengfu Lu* and Yuefa Gong Org. Lett. 2019, 21, 8464-8468, “Polarity-Reversed Addition of Enol Ethers to Imines under Visible Light: Redox-Neutral Access to Azide-Containing Amino Acids”

20. Sen Yang, Shuangyu Zhu, Dengfu Lu* and Yuefa Gong* Org. Lett. 2019, 21, 2019-2024, "Formylation of Fluoroalkyl Imines through Visible-Light-Enabled H-Atom Transfer Catalysis: Access to Fluorinated α-Amino Aldehydes"

19. Sen Yang, Dengfu Lu, Hengrui Huo, Fan Luo*, and Yuefa Gong* Org. Lett. 2018, 20, 6943, "Construction of Substituted 2-Aminophenols via Formal [3 + 3] Cycloaddition of Alkyl 2-Aroyl-1-chlorocyclopropanecarboxylate with in Situ Generated Enamines"

18 Haotian Li, Yuequan Zhu, Dengfu Lu* and Yuefa Gong* Org. Biomol. Chem., 2018,16, 5907-5912, "Regioselective Addition of Phosphites to Acyl Cyclopropanes and Following Rearrangements: A Facile Access to Enol Phosphates"

17. Liu Cao, Hengrui Huo, Haipeng Zeng, Yu Yu, Dengfu Lu * and Yuefa Gong * Adv. Synth. Catal. 2018,2018, 360, 4764 – 4773, "One-Pot Synthesis of Quinazolin-4(3H)-ones through Anodic Oxidation and the Related Mechanistic Studies"

16. Sen Yang, Dengfu Lu, Yuequan Zhu, Mei Shi, Fan Luo*, and Yuefa Gong*  J. Org. Chem. 2018, 83, 6681−6689, "Ethyl 6-Hydroxyfulvene-1-Carboxylate: A Reagent Discriminating Primary Amines from Secondary Amines"

15. Haipeng Zeng, Sen Yang, Haotian Li, Dengfu Lu*, Yuefa Gong*, and Jin-Tao Zhu, “Site-Specific Functionalization of 1,3-Dioxolane with Imines: A Radical Chain Approach to Masked α-Amino Aldehydes” J. Org. Chem. 2018, just accepted, DOI: 10.1021/acs.joc.8b00715

14. Haipeng Zeng, Dengfu Lu*, and Yuefa Gong*  “Direct Metal-free C-H Functionalization of Cyclic Ethers with Schiff Bases through an Azobisisobutyronitrile (AIBN) Initiated Radical Chain Process” Eur. J. Org. Chem. 2017, 29, 7231.

博士后阶段：

13. Shou-Jie Shen, Cheng-Liang Zhu, Dengfu Lu, and Hao Xu, Iron-Catalyzed Direct Olefin Diazidation via Peroxyester Activation Promoted by Nitrogen-Based Ligands. ACS Catal. 2018,  just accepted,10.1021/acscatal.8b00821.

12. Lu, D.-F^ǂ; Zhu, C.-L.^ǂ; Sears, J. D.; Xu, H.* Iron(II) Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion, J. Am. Chem. Soc., 2016, 138, 11360–11367. (并列第一作者)

11. Cheng‐Liang Zhu, Deng‐Fu Lu, Hao Xu, Iron(II) Bis(trifluoromethanesulfonyl)-imide, Encyclopedia of Reagents for Organic Synthesis.

10. Yuan, Y.-A. ^ǂ; Lu, D.-F. ^ǂ; Chen Y.-R; Xu, H. * “Iron(II)-Catalyzed Direct Diazidation of a Broad Range of Olefins” Angew. Chem., Int, Ed. 2015, 55, 534–538. (并列第一作者)

9. Lu, D.-F.; Zhu, C.-L.; Jia, Z.-X.; Xu, H.* “Iron(II)-Catalyzed Intermolecular Amino-Oxygenation of Olefins through N-O Bond Cleavage of Functionalized Hydroxylamines” J. Am. Chem. Soc. 2014, 136, 1318 6.    Highlighted in: Synfacts 2014, 10, 1278.

8. Lu, D.-F.; Liu, G.-S.; Zhu, C.-L.; Yuan, B.; Xu, H.* “Iron(II)-Catalyzed Intramolecular Olefin Aminofluorination.” Org. Lett. 2014, 16, 2912.    Highlighted in: Synfacts 2014, 10, 844.

7. Lu, D.-F.; Zhu, C.-L.; Xu, H.* “Copper(I)-Catalyzed Diastereoselective Hydroxytrifluoromethylation of Dienes Accelerated by Phosphine Ligands” Chem. Sci. 2013, 4, 2478.    Highlighted in:  Synfacts 2013, 9, 1295.

6. Zhu, C.-L.; Lu, D.-F.; Sears, J. D.; Jia, Z.-X.; Xu, H.^* “Practical Synthetic Procedures of the Iron-Catalyzed Intermolecular Olefin Aminohydroxylation Using Functionalized Hydroxylamines” Synthesis, 2016, DOI: 10.1055/s-0035-1562515 (Invited Practical Synthetic Procedure Contribution).

博士阶段：

5. Lu, D.; Zhou, Y.; Li, Y.; Yan, S.; Gong, Y.* “Copper(II) Catalyzed Asymmetric Henry Reaction of  o-Alkynylbenzaldehydes and Following Gold(I) Mediated Cycloisomerization: An Enantioselective Route to Chiral 1-H-isochromenes and 1,3-Dihydroisobenzofurans” J. Org. Chem. 2011, 76, 8869.

4. Lu, D.; Li, Y.; Gong, Y.* “Organocatalytic Asymmetric Tandem Michael Addition- Hemiacetalization: A Route to Chiral Dihydrocoumarins, Chromanes, and 4H-Chromenes” J. Org. Chem. 2010, 75, 6900.

3. Lu, D.; Li, Y.; Gong, Y.* Wang, W. “Prolylprolinol-Catalyzed Asymmetric Michael Addition of Aliphatic Aldehydes to Nitroalkenes” Adv. Synth. Catal. 2010, 352, 644-650.

2. Luo, F.; Lu, D.; Gong, Y.* “Enantioselective bioreduction of 2-fluoro-2-alken-1-ols mediated by Saccharomyces cerevisiae” J. Mol. Catal. B: Enzymatic 2011, 70, 10

1.Zhang, F.; Wei, M.; Dong, J.; Zhou Y.; Lu, D.; Gong, Y.*; Yang, X. “A Recyclable Organocascade Reaction System: Stereoselective Precipitation of Optically Active cis-δ-Lactols with Quaternary Stereocenters during the Michael-Hemiacetalization Reaction” Adv. Synth. Catal. 2010, 352, 2875.